Marine Plastic Pollution (MPP) is an increasing global concern, and its impact has been gradually documented across the world. Tackling marine pollution is one of the most pressing environmental challenges for Asia and the Pacific. ESCAP member States have recently ratified their commitment to addressing this issue through Resolution 76/1 on "Strengthening cooperation to promote the conservation and sustainable use of the oceans, seas and marine resources for sustainable development in Asia and the Pacific." The South Asian region (SAR) has 2 of the most polluted rivers in the world (the Ganges and the Indus).1 A large portion of the marine litter found in these polluted rivers contains plastics from land-based sources, mainly from urban areas.2 The transboundary nature of marine plastic pollution requires early recognition by every country to control the magnitude of marine pollution before it gets out of control. This policy brief provides a background on marine plastic pollution, including issues affecting South Asia and policy recommendations for decision-makers and stakeholders' uptake.