This policy brief examines the Doha Programme of Action for Least Developed Countries for the Decade 2022-2031 (DPoA), particularly its alignment and synergies with the Sustainable Development Goals (SDGs). Adopted in 2022, the DPoA addresses persistent challenges faced by least developed countries (LDCs) and provides tailored actions to meet their unique needs, with key focus areas including investing in people, supporting structural transformation, and mobilizing partnerships for sustainable graduation. As the DPoA aims to support the sustainable development of LDCs, its implementation should also be seen as instrumental in achieving the SDGs. To understand how the DPoA and the 2030 Agenda are complementary, this policy brief maps the 116 DPoA targets onto the SDG targets and reveals that the DPoA aligns with 14 SDGs, with approximately two-thirds of its targets closely matching or resembling SDG targets. This highlights significant potential for joint implementation. The brief also discusses how leveraging the SDG review process, particularly the voluntary national review (VNR) process, in DPoA’s review mechanisms can streamline efforts, reduce costs, enhance horizontal policy coherence, and ultimately support the sustainable development of LDCs.