Cross-border infrastructure networks are critical for improving regional connectivity, their financing has however been challenging. This paper examines whether Public-Private Partnerships (PPP) may contribute to their development and reviews past experience with this type of financing arrangements in the energy, transport and telecommunication sectors. By involving several countries, cross-border projects face specific challenges as these projects are by nature more complex, face augmented political risks and necessitate higher level of coordination. To support countries in financing cross-border projects, the paper studies these challenges in detail. It also highlights the policy actions required to achieve enhanced regional connectivity. It stresses, for instance, the importance of supporting intergovernmental platforms where international networks can be planned, regulatory hurdles tackled and financing arrangements structured. Developing guidelines for these type of projects would also help countries in their efforts to enhance regional connectivity. The paper concludes by recognizing the potential of PPP for cross-border projects, though it acknowledges that supportive policy actions from participating governments will be required for their success as well as a strong high-level political backing.