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The Asia-Pacific region has made considerable progress on improving economic and social welfare over the last decade. Water resources have contributed greatly to this transformation through water and sanitation hygiene (WASH), provision of basic services, agricultural expansion, food security and nutrition, and ecosystem services. This was most notable during COVID-19 pandemic, where WASH and innovations in WASH service delivery were at the forefront of disease prevention. As a result, since the adoption of the 2030 Agenda for Sustainable Development and the Sustainable Development Goals (SDGs), progress has been made to elevate water issues at the national and regional levels across the Asia-Pacific region. However, the region is far from being on track to meet SDG 6 targets as outlined in the 2030 Agenda for Sustainable Development. Access to sustainable water resources is increasingly threatened due to overuse and pollution, growing populations, increasing water demands, water scarcity, a changing climate, rapid urbanisation, inadequate sanitation services and lack of transboundary cooperation. Continuous water availability—both in sufficient quantity and adequate quality—is fundamental to the expansion of safe drinking water services under SDG 6. Despite the urgent need for solutions, it is often challenging to know where to begin. The most notable threat to SDG 6 progress is water stress. In the effort to ensure food security for growing populations, the status of available freshwater resources has largely been neglected in some of the most consequential parts of the Asia-Pacific region. The Asia-Pacific region is currently not on track to achieve any of the SDG 6 targets by 2030, as progress falls short of where the region should be by 2022. The region must take action to reverse negative trends for target 6.6, protect and restore water-related ecosystems, and target 6.b, community participation in water and sanitation management. While there has been a substantial effort to increase aid to the least developed countries for water supply and sanitation, 1.9 billion people throughout the region still lack access to safely managed drinking water and sanitation services, and 1.3 billion people do not have basic handwashing facilities. Despite progress in some components of SDG 6, such as the reduction of open defecation, overall development is not on track to achieve the specific target goals by 2030.